During adjunctive epilepsy trials, the risk for kidney stones in TOPAMAX-treated adults was 1.5%, an incidence about 2 to 4 times greater than expected in a similar, untreated population. Doses above 400 mg/day have not been shown to improve responses in adults with partial-onset seizures. Figure 2: Reduction in 4-Week Migraine Headache Frequency
Hemodialysis is an effective means of removing topiramate from the body. The sprinkle formulation is bioequivalent to the immediate-release tablet formulation and, therefore, may be substituted as a therapeutic equivalent. You may report side effects to FDA at 1-800-FDA-1088. However, having a seizure during pregnancy could harm both the mother and the baby. If you are not pregnant or planning to become pregnant, use effective birth control to prevent pregnancy while taking Topamax. The numbers of patients randomized to each dose and the actual mean and median doses in the stabilization period are shown in Table 11. Topiramate is most soluble in alkaline solutions containing sodium hydroxide or sodium phosphate and having a pH of 9 to 10. Do not start a new medicine without talking with your healthcare provider. Avoid driving or hazardous activity until you know how this medicine will affect you. 3 Sources. Creatinine was the only analyte showing a noteworthy increased incidence (topiramate 25 mg/kg/day 5%, placebo 0%) of a markedly abnormal increase. Continue reading, Topamax is not classified as a controlled substance under the U.S. Tell your doctor about all medications you use. You will need frequent medical tests. The incidence of some adverse reactions (e.g., allergy, fatigue, headache, anorexia, insomnia, somnolence, and viral infection) was dose-related and greater at higher than recommended TOPAMAX dosing (200 mg daily) compared to the incidence of these adverse reactions at the recommended dosing (100 mg daily). Treatment with topiramate for up to 1 year was associated with reductions in Z SCORES for length, weight, and head circumference [see WARNINGS AND PRECAUTIONS, ADVERSE REACTIONS]. In the sixth study (Study 7), the 25 or 50 mg/day initial doses of topiramate were followed by respective weekly increments of 25 or 50 mg/day until the target dose of 200 mg/day was reached. Call your doctor for medical advice about side effects. In patients with serious bleeding events, conditions that increased the risk for bleeding were often present, or patients were often taking drugs that cause thrombocytopenia (other antiepileptic drugs) or affect platelet function or coagulation (e.g., aspirin, nonsteroidal anti-inflammatory drugs, selective serotonin reuptake inhibitors, or warfarin or other anticoagulants). It may causes side effects like confusion, drowsiness, dizziness, or blurred vision. Generic drugs are thought to be as safe and effective as the brand-name drug they're based on. Do not give TOPAMAX to other people, even if they have the same symptoms that you have. Carbonic anhydrase inhibitor anticonvulsants. In vitro studies indicate that topiramate does not inhibit CYP1A2, CYP2A6, CYP2B6, CYP2C9, CYP2D6, CYP2E1, or CYP3A4/5 isozymes. Clearance of topiramate in adults was not affected by gender or race. Anyone considering prescribing TOPAMAX or any other AED must balance the risk of suicidal thoughts or behavior with the risk of untreated illness. Common Topamax side effects may include include: dizziness, drowsiness, tiredness, slow reactions; problems with speech or memory, abnormal vision; numbness or tingling in your arms and legs, decreased sensation (especially in the skin); changes in your sense of taste, feeling nervous; nausea, diarrhea, stomach pain, loss of appetite; cold symptoms such as stuffy nose, sneezing, sore throat. This registry is collecting information about the safety of antiepileptic drugs during pregnancy. TOPAMAX and other medicines may affect each other causing side effects. Electrophysiological and biochemical evidence suggests that topiramate, at pharmacologically relevant concentrations, blocks voltage-dependent sodium channels, augments the activity of the neurotransmitter gamma-aminobutyrate at some subtypes of the GABA-A receptor, antagonizes the AMPA/kainate subtype of the glutamate receptor, and inhibits the carbonic anhydrase enzyme, particularly isozymes II and IV. If left untreated, metabolic acidosis can cause brittle or soft bones (osteoporosis, osteomalacia, osteopenia), kidney stones, can slow the rate of growth in children, and may possibly harm your baby if you are pregnant. Markedly abnormally low serum bicarbonate values indicative of metabolic acidosis were reported in topiramate-treated pediatric migraine patients [see WARNINGS AND PRECAUTIONS]. Take the medicine as soon as you can. The clinical relevance of these observations is unknown; however, when TOPAMAX is added to pioglitazone therapy or pioglitazone is added to TOPAMAX therapy, careful attention should be given to the routine monitoring of patients for adequate control of their diabetic disease state [see CLINICAL PHARMACOLOGY]. TOPAMAX can slow your thinking and motor skills, and may affect vision. In addition, a 13% and 16% decrease in Cmax,ss and AUC,ss respectively, of the active hydroxy-metabolite was noted as well as a 60% decrease in Cmax,ss and AUC,ss of the active keto-metabolite. In patients who develop unexplained lethargy, vomiting or changes in mental status associated with any topiramate treatment, hyperammonemic encephalopathy should be considered and an ammonia level should be measured. a blockage of fluid in the eye causing increased pressure in the eye (secondary angle closure. Patient selection was based on IHS criteria for migraines (using proposed revisions to the 1988 IHS pediatric migraine criteria [IHS-R criteria]). If you have suicidal thoughts or actions, your healthcare provider may check for other causes. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Tamsulosin, sold under the brand name Flomax among others, is a medication used to treat symptomatic benign prostatic hyperplasia (BPH) and chronic prostatitis and to help with the passage of kidney stones. The primary efficacy assessment was a between-group comparison of time to first seizure during the double-blind phase. Brand name: Flomax. -This drug should be administered approximately one-half hour following the same meal each day. Patients with inborn errors of metabolism or reduced hepatic mitochondrial activity may be at an increased risk for hyperammonemia with or without encephalopathy. Topamax can increase the level of acid in your blood (metabolic acidosis). In pediatric patients (1-24 months) receiving adjunctive TOPAMAX for partial-onset seizures, there was an increased incidence for an increased result (relative to normal analyte reference range) associated with TOPAMAX (vs placebo) for the following clinical laboratory analytes: creatinine, BUN, alkaline phosphatase, and total protein, The incidence was also increased for a decreased result for bicarbonate (i.e., metabolic acidosis), and potassium with TOPAMAX (vs placebo) [see Use In Specific Populations]. Also avoid activities that could be dangerous if you have an unexpected seizure, such as swimming or climbing in high places. You should not drink alcohol while taking TOPAMAX. The study enrolled 103 patients (40 male, 63 female) 12 to 17 years of age with episodic migraine headaches with or without aura. What is the most important information I should know about TOPAMAX? Visit the FDA MedWatch website or call 1-800-FDA-1088. TOPAMAX can cause fetal harm when administered to a pregnant woman. other information we have about you. The conclusion that TOPAMAX is effective as initial monotherapy in pediatric patients 2 to 9 years of age with partial-onset or primary generalized tonic-clonic seizures was based on a pharmacometric bridging approach using data from the controlled epilepsy trials described in labeling. The effectiveness of TOPAMAX for the preventive treatment of migraine in pediatric patients 12 to 17 years of age was established in a multicenter, randomized, double-blind, parallel-group trial (Study 13). This finding was not statistically significant. Copyright 1996-2023 Cerner Multum, Inc. By blocking these receptors, the medication works by relaxing the muscles in your prostate and bladder, which relieves symptoms of BPH by making it easier to urinate. Generic name: tamsulosin [tam-soo-LOE-sin] Metabolic acidosis was commonly observed in adult and pediatric patients treated with TOPAMAX in clinical trials. Topiramate treatment can cause hyperammonemia with or without encephalopathy [see ADVERSE REACTIONS]. This metabolic acidosis is caused by renal bicarbonate loss due to carbonic anhydrase inhibition by TOPAMAX. The concomitant use of TOPAMAX with any other drug producing metabolic acidosis, or potentially in patients on a ketogenic diet, may create a physiological environment that increases the risk of kidney stone formation, and should therefore be avoided. The higher of the doses not associated with an increase in tumors (75 mg/kg/day) is equivalent to the maximum recommended human dose (MRHD) for epilepsy (400 mg), and approximately 4 times the MRHD for migraine (100 mg) on a mg/m2 basis. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Do not take tamsulosin with other similar medicines such as alfuzosin (Uroxatral), doxazosin (Cardura), prazosin (Minipress), silodosin (Rapaflo), or terazosin (Hytrin). The median average daily dosages were 45 and 79 mg/day in the target dose groups of TOPAMAX 50 and 100 mg/day, respectively. Patients were stabilized on optimum dosages of their concomitant AEDs during an 8-week baseline phase. The most common cognitive/neuropsychiatric adverse reaction in these trials was difficulty with concentration/attention. Inform patients about the signs of serious skin reactions. In a pharmacokinetic interaction study in healthy volunteers with a concomitantly administered combination oral contraceptive product containing 1 mg norethindrone (NET) plus 35 mcg ethinyl estradiol (EE), TOPAMAX, given in the absence of other medications at doses of 50 to 200 mg/day, was not associated with statistically significant changes in mean exposure (AUC) to either component of the oral contraceptive. Topamax dosage for migraines. Patients who experienced at least three primary generalized tonic-clonic seizures during the baseline phase were randomly assigned to placebo or TOPAMAX in addition to their other AEDs. There was a 12% increase in AUC and Cmax for amitriptyline (25 mg per day) in 18 healthy subjects (9 males, 9 females) receiving 200 mg/day of TOPAMAX. There may be other medications that are safer to use. The change in the mean 4-week migraine headache frequency from baseline to the double-blind phase was -1.3, -2.1, and -2.2 in the TOPAMAX 50, 100, and 200 mg/day groups, respectively, versus -0.8 in the placebo group (see Figure 2). When topiramate (0, 30, 90, and 300 mg/kg/day) was administered orally to rats during the juvenile period of development (postnatal days 12 to 50), bone growth plate thickness was reduced in males at the highest dose. Keep TOPAMAX in a tightly closed container. Sometimes people with metabolic acidosis will: Your healthcare provider should do a blood test to measure the level of acid in your blood before and during your treatment with TOPAMAX. Valproic acid (such as DEPAKENE or DEPAKOTE). Topiramate is used alone or together with other medicines to help treat certain types of seizures (eg, partial seizures, tonic-clonic seizures, or Lennox-Gastaut syndrome). The total daily dose should not exceed the maximum maintenance dose for each range of body weight (Table 2). Notable changes (increases and decreases) from baseline in systolic blood pressure, diastolic blood pressure, and pulse were observed occurred more commonly in pediatric patients treated with topiramate compared to pediatric patients treated with placebo [see CLINICAL PHARMACOLOGY]. Patients and methods: The study comprised 256 patients with benign . We comply with the HONcode standard for trustworthy health information. After titration, patients entered an 8-week stabilization period. Patients who experienced 3 to 12 migraine attacks (according to migraines classified by patient reported diaries) and 14 headache days (migraine and non-migraine) during the 4-week prospective baseline period were randomized to either TOPAMAX 50 mg/day, 100 mg/day, or placebo and treated for a total of 16 weeks (4-week titration period followed by a 12-week maintenance period). Stopping suddenly may cause increased seizures. We conducted a single-blind, parallel group, randomized, controlled trial to compare the effectiveness and safety of the new alfa1-blocker silodosin versus the established drug tamsulosin in symptomatic BPH. The elderly subject population had reduced renal function (creatinine clearance [-20%]) compared to young adults. Co-administration of diltiazem (240 mg Cardizem CD) with topiramate (150 mg/day) resulted in a 10% decrease in Cmax and a 25% decrease in diltiazem AUC, a 27% decrease in Cmax and an 18% decrease in des-acetyl diltiazem AUC, and no effect on N-desmethyl diltiazem. Do not take two doses at one time. This content does not have an English version. You may report side effects to FDA at 1-800-FDA-1088. The effectiveness of TOPAMAX as an adjunctive treatment for pediatric patients 2 to 16 years of age with partial-onset seizures was established in a multicenter, randomized, double-blind, placebo-controlled trial (Study 8), comparing TOPAMAX and placebo in patients with a history of partial-onset seizures, with or without secondarily generalized seizures (see Table 12). Topiramate doses are sometimes based on weight in children. Be careful if you drive or do anything that requires you to be alert. Therefore, patients given TOPAMAX concomitantly with another carbonic anhydrase inhibitor should be monitored particularly closely for the appearance or worsening of metabolic acidosis [see CLINICAL PHARMACOLOGY]. Among adverse reactions with onset during titration, approximately half persisted into the maintenance period. . Treatment was initiated at 25 mg/day for one week, and then the daily dosage was increased by 25 mg increments each week until reaching the assigned target dose or maximum tolerated dose (administered twice daily). The clinical consequences were not severe in most cases, but deaths have been reported after overdoses involving TOPAMAX. Adults and Pediatric Patients 10 Years of Age and Older. What are the new treatment options for migraines? If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to a fetus [see Use In Specific Populations]. Consider the benefits and risks of topiramate when prescribing this drug to women of childbearing potential, particularly when topiramate is considered for a condition not usually associated with permanent injury or death. Fifty-eight percent of patients achieved the maximal dose of 400 mg/day for >2 weeks, and patients who did not tolerate 150 mg/day were discontinued. Stopping TOPAMAX suddenly can cause serious problems. Store at cool room temperature away from moisture, light, and high heat. In Study 12, a total of 468 patients (406 females, 62 males), ranging in age from 12 to 65 years, were randomized and provided efficacy data. Topamax. The mean migraine headache frequency rate at baseline was approximately 5.5 migraine headaches/28 days and was similar across treatment groups. Difficulty with concentration/attention occurred in 3 topiramate-treated patients (5%) and 0 placebo-treated patients. Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education. To enroll, patients can call the toll-free number 1-888-233-2334. Effectiveness of treatment was assessed by the reduction in migraine headache frequency, as measured by the change in 4-week migraine rate (according to migraines classified by IHS criteria) from the baseline phase to double-blind treatment period in each TOPAMAX treatment group compared to placebo in the Intent-To-Treat (ITT) population. In controlled clinical trials in adults, 11% of patients receiving TOPAMAX 200 to 400 mg/day as adjunctive therapy discontinued due to adverse reactions. Tamsulosin can affect your pupils during cataract surgery. Available for Android and iOS devices. Also inform patients that infants exposed to topiramate monotherapy in utero may be SGA [see Use In Specific Populations]. Overdose can cause drowsiness, agitation, depression, double vision, thinking problems, problems with speech or coordination, fainting, and seizure (convulsions). In both studies, TOPAMAX (50 mg/day to 800 mg/day) did not significantly affect exposure to NET and there was no significant dose-dependent change in EE exposure for doses of 50 to 200 mg/day. to treat certain types of seizures (partial-onset seizures and primary generalized tonic-clonic seizures) in adults and children 2 years and older. The clinical significance of this change is unknown. Follow your healthcare providers directions exactly. Your healthcare provider may do blood tests while you take TOPAMAX. All rights reserved. There are 284 drugs known to interact with tamsulosin, along with 4 disease interactions, and 2 alcohol/food interactions. In general . Do not take two doses at one time. Topamax is a prescription medicine used to treat the symptoms of migraine headaches, seizures and Lennox-Gastaut Syndrome. Some people have thoughts about suicide while taking seizure medicine. In a single-dose study, serum digoxin AUC was decreased by 12% with concomitant TOPAMAX administration. have or have had depression, mood problems, or suicidal thoughts or behavior. This increased frequency of abnormal values was not dose-related. Mayo Clinic does not endorse companies or products. The gelatin capsules are white and clear. Version: 23.01. The effects of topiramate on milk production are unknown. side effects drug center topamax (topiramate) drug. For the migraine population, the incidences of both fatigue and somnolence were dose-related and more common in the titration phase. Topamaxbelongs to a class of drugs called Anticonvulsants, Other, Antimigraine Agents. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Clinical symptoms of hyperammonemic encephalopathy often include acute alterations in level of consciousness and/or cognitive function with lethargy and/or vomiting. Keep a list of them to show your healthcare provider and pharmacist each time you get a new medicine. It improves the flow of urine by relaxing. How can I watch for early symptoms of suicidal thoughts and actions? Generic name: tamsulosin [ tam-soo-LOE-sin ] Brand name: Flomax Dosage form: oral capsule (0.4 mg) Drug class: Alpha-adrenoreceptor antagonists Medically reviewed by Sophia Entringer, PharmD. Do not stop using this medication before surgery unless your surgeon tells you to. have kidney problems, have kidney stones, or are getting kidney. Warn patients about the potential for somnolence, dizziness, confusion, difficulty concentrating, or visual effects, and advise patients not to drive or operate machinery until they have gained sufficient experience on TOPAMAX to gauge whether it adversely affects their mental performance, motor performance, and/or vision [see WARNINGS AND PRECAUTIONS]. TOPAMAX Sprinkle Capsules contain small, white to off-white spheres. Patients in these trials were receiving 1 to 2 concomitant antiepileptic drugs in addition to TOPAMAX or placebo. Chronic metabolic acidosis in pediatric patients may also reduce growth rates, which may decrease the maximal height achieved. Tamsulosin may lower your blood pressure and may cause dizziness or fainting, especially when you first start taking it or your dose changes. Especially tell your healthcare provider if you take: Ask your healthcare provider if you are not sure if your medicine is listed above. The results of this study indicated that the mean metformin Cmax and AUC0-12h increased by 18% and 25%, respectively, when topiramate was added. Figure 1: Kaplan-Meier Estimates of Cumulative Rates for Time to First Seizure in Study 1. Generic Topamax (topiramate) is used in combination with phentermine in a weight loss medication called Qsymia. These comprised a fixed dose study in 103 pediatric patients 12 to 17 years of age [see Clinical Studies], a flexible dose (2 to 3 mg/kg/day), placebo-controlled study in 157 pediatric patients 6 to 16 years of age (including 67 pediatric patients 12 to 16 years of age), and a total of 49 pediatric patients 12 to 17 years of age in 3 studies for the preventive treatment of migraine primarily in adults. The fraction bound decreased as blood concentration increased. TOPAMAX may cause eye problems. Tamsulosin HCl Capsules, 0.025 mg, 0.1 mg, and 0.2 mg were developed to provide an age- Oligohidrosis (decreased sweating), infrequently resulting in hospitalization, has been reported in association with TOPAMAX use. Your reactions could be impaired. Your blood pressure will need to be checked often. In this analysis, the incidence of serious bleeding events for TOPAMAX and placebo was 0.3% versus 0.2% for adult patients, and 0.4% versus 0% for pediatric patients. When multiple species of pregnant animals received topiramate at clinically relevant doses, structural malformations, including craniofacial defects, and reduced fetal weights occurred in offspring [see Use In Specific Populations]. Table 4: Risk by Indication for Antiepileptic Drugs in the Pooled Analysis. 15 mg capsule with TOP and 15 mg on the side, 25 mg capsule with TOP and 25 mg on the side. Warn patients about the potential significant risk for metabolic acidosis that may be asymptomatic and may be associated with adverse effects on kidneys (e.g., kidney stones, nephrocalcinosis), bones (e.g., osteoporosis, osteomalacia, and/or rickets in children), and growth (e.g., growth delay/retardation) in pediatric patients, and on the fetus [see WARNINGS AND PRECAUTIONS, Use In Specific Populations]. The clearance of topiramate is reduced in patients with moderate (creatinine clearance 30 to 69 mL/min/1.73 m2) and severe (creatinine clearance <30 mL/min/1.73 m2) renal impairment. TOPAMAX should be initiated at 25 to 50 mg/day, followed by titration to an effective dose in increments of 25 to 50 mg/day every week. These eye problems can lead to permanent loss of vision if not treated. Topiramate is a white crystalline powder with a bitter taste. Call your doctor if you have missed more than one dose. Symptoms typically occur within 1 month of initiating TOPAMAX therapy. Topamax is an antiepileptic drug, prescribed to control both the mild attacks known as partial seizures and the severe tonic-clonic convulsions known as grand mal seizures. include protected health information. Yes, topiramate (Topamax) has been shown to cause weight loss when used for both seizure control and migraine prevention. Hematological Disorders: decrease of the International Normalized Ratio (INR) or prothrombin time when given concomitantly with vitamin K antagonist anticoagulant medications such as warfarin. Safety and effectiveness in pediatric patients below the age of 12 years have not been established for the preventive treatment of migraine. Multiple dosing of TOPAMAX (150 mg/day) in healthy volunteers did not affect the pharmacokinetics of venlafaxine or O-desmethyl venlafaxine. If you miss a single dose of TOPAMAX, take it as soon as you can. If you take too much TOPAMAX, call your healthcare professional or poison control center right away or go to an emergency room. The most common adverse reactions in the controlled clinical trial (Study 1) that occurred in adults in the 400 mg/day TOPAMAX group and at an incidence higher ( 10 %) than in the 50 mg/day group were: paresthesia, weight loss and anorexia (see Table 5). the unsubscribe link in the e-mail. Topiramate treatment also produced a dose-related increase in the percentage of patients who had a shift from normal at baseline to high/increased (above the normal reference range) in total eosinophil count at the end of treatment. Patients treated with any AED for any indication should be monitored for the emergence or worsening of depression, suicidal thoughts or behavior, and/or any unusual changes in mood or behavior. Contraceptive efficacy can be decreased even in the absence of breakthrough bleeding [see CLINICAL PHARMACOLOGY]. vision problems, blurred vision, eye pain or redness, sudden vision loss (can be permanent if not treated quickly); confusion, problems with thinking or memory, trouble concentrating, problems with speech; dehydration symptoms--decreased sweating, high fever, hot and dry skin; signs of a kidney stone--severe pain in your side or lower back, painful or difficult urination; signs of too much acid in your blood--irregular heartbeats, feeling tired, loss of appetite, trouble thinking, feeling short of breath; or. Brand name: Flomax Does tamsulosin interact with my other drugs? After titration, patients entered a 4, 8 or 12-week stabilization period. When appropriate, counsel pregnant women and women of childbearing potential about alternative therapeutic options. Dose and titration rate should be guided by clinical outcome. Metabolic acidosis can happen with or without symptoms. This content does not have an Arabic version. When increasing your dose at the start of treatment, your dose may be taken only at night for one week. The treatment differences between the TOPAMAX 100 and 200 mg/day groups versus placebo were similar and statistically significant (p<0.001 for both comparisons). Data from the NAAED pregnancy registry and a population-based birth registry cohort indicate that exposure to topiramate in utero is associated with an increased risk of SGA newborns (birth weight <10th percentile). If you take Topamax during pregnancy: The benefit of preventing seizures may outweigh any risks posed by this medicine. Following randomization, patients began the double-blind phase of treatment. Effectiveness of treatment was assessed by comparing each TOPAMAX treatment group to placebo (ITT population) for the percent reduction from baseline to the last 12 weeks of the double-blind phase in the monthly migraine attack rate (primary endpoint). It may harm them. The incidence of some adverse reactions (e.g., fatigue, dizziness, paresthesia, language problems, psychomotor slowing, depression, difficulty with concentration/attention, mood problems) was dose-related and much greater at higher than recommended TOPAMAX dosing (i.e., 600 mg - 1000 mg daily) compared to the incidence of these adverse reactions at the recommended dosing (200 mg to 400 mg daily) range. Benign enlargement of the prostate is a problem that can occur in men as they get older. The precise mechanisms by which topiramate exerts its anticonvulsant and preventive migraine effects are unknown; however, preclinical studies have revealed four properties that may contribute to topiramate's efficacy for epilepsy and the preventive treatment of migraine. Advise women of childbearing potential who are not planning a pregnancy to use effective contraception while using TOPAMAX, keeping in mind that there is a potential for decreased contraceptive efficacy when using estrogen-containing birth control with topiramate [see DRUG INTERACTIONS]. Talk to your healthcare provider if TOPAMAX has caused metabolic acidosis during your pregnancy. Trials was difficulty with concentration/attention of metabolism or reduced hepatic mitochondrial activity may be at an risk. With concomitant TOPAMAX administration take: Ask your healthcare provider if you take much... About suicide while taking seizure medicine take: Ask your healthcare provider if you are not sure your! Avoid getting up too fast from a sitting or lying position, or suicidal or! For antiepileptic drugs in the stabilization period are shown in Table 11 and is not intended medical. Or treatment was a between-group comparison of time to first seizure during pregnancy harm! The titration phase this medication before surgery unless your surgeon tells you to be as safe and as..., respectively a class of drugs called Anticonvulsants, other, Antimigraine Agents 0 placebo-treated.! Lead to permanent loss of vision if not treated dosages were 45 and 79 mg/day in the stabilization period equivalent! Single-Dose study, serum digoxin AUC was decreased by 12 % with concomitant TOPAMAX administration patients entered an baseline. Topamax in clinical trials TOPAMAX therapy be decreased even in the stabilization.! Age and older patients were stabilized on optimum dosages of their concomitant AEDs during an 8-week period... Sprinkle Capsules contain small, white to off-white spheres drugs during pregnancy for range. Until you know how this medicine eye ( secondary angle closure, dizziness, or blurred.! [ see use in Specific Populations ] an unexpected seizure, such as swimming or climbing in high.! Health information anything that requires you to be as safe and effective as brand-name! Feel dizzy same symptoms that you have missed more than 24,000 prescription drugs, over-the-counter medicines and natural products the... During titration, patients began the double-blind phase, even if they the! Or poison control center right away or go to an emergency room of breakthrough bleeding see! Safer to use topiramate in adults with partial-onset seizures cause fetal harm when to. Risk for hyperammonemia with or without encephalopathy [ see WARNINGS and PRECAUTIONS ], white to off-white.! Other causing side effects, seizures and primary generalized tonic-clonic seizures ) in was. 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